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Answer: Difference between lipoma and liposarcoma. A lipoma is a benign (non-cancerous) tumor of fat cells and a liposarcoma is a malignant (cancerous) tumor of fat cells. A biopsy should be able to determine the difference between the two. Michael I. Echavez, MD Board Certified Facial Plastic Surgeon. ( 25). The differential diagnosis of a lipoma in the groin will include groin hernias, safina varex, lymphadenopathy, hydrocele and sarcoma Lipomas in the stomach are very rare, representing less than 3% of all benign gastric neoplasms Lipomas And Liver Function Liver lipoma is a rare benign mesenchymal tumour without malignant degeneration The normal.